Gamma/E-beam Indicators

This acceptance comes at an especially critical time for the FDA to continue our important work to mitigate ethylene oxide sterilized device shortages. The FDA believes the Ethylene Oxide Sterilization Master File Pilot Program should result in sterilization facilities using a greatly reduced amount of ethylene oxide while still providing robust patient safeguards. The FDA will continue in its efforts to reduce over-reliance on ethylene oxide for medical device sterilization and will provide updates on future Master File acceptances. Medical devices are sterilized in a variety of ways including using moist heat steam , dry heat, radiation, ethylene oxide gas, vaporized hydrogen peroxide, and other sterilization methods for example, chlorine dioxide gas, vaporized peracetic acid, and nitrogen dioxide. Ethylene oxide sterilization is an important sterilization method that manufacturers widely use to keep medical devices safe. For many medical devices, sterilization with ethylene oxide may be the only method that effectively sterilizes and does not damage the device during the sterilization process. Medical devices made from certain polymers plastic or resin , metals, or glass, or that have multiple layers of packaging or hard-to-reach places for example, catheters are likely to be sterilized with ethylene oxide. Literature shows that about fifty percent 1 , 2 , 3 of all sterile medical devices in the U. The types of devices that are sterilized with ethylene oxide range from devices used in general health care practices for example, wound dressings to more specialized devices used to treat specific areas of the body for example, stents.

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The proposed research projects are expected to be multidisciplinary with the ultimate aim of examining the relative biological effectiveness RBE of high linear energy transfer high LET radiation on cell and tissue targets in comparison to low linear energy transfer low LET radiation. The overall goal of the research is to establish a firm scientific basis for RBE models of high LET radiation and determine potential benefits in cancer treatment.

All applications are due by PM local time of applicant organization.

In situ U-Pb dating combined with SEM images on zircon crystals represent a powerful Operating conditions were an accelerating voltage of 15 kV with a beam can be related to an Eo-Variscan activity started in Silurian-Ordovician times.

It is very important for medical devices and pharmaceuticals to maintain sterility over the long term after they have undergone terminal sterilization. Many medical devices and pharmaceuticals are not used immediately after terminal sterilization and are stored until the end-user is ready for them. Proper packaging, terminal sterilization, distribution and storage processes must take this into account. Re-sterilizing, re-packaging or discarding a package because of loss of sterility can result in loss of time, resources and brand image.

This test was designed to have a more severe microbial challenge than typical real-world conditions. First, the contents of the packages were tested for initial sterility. Then, every four months throughout the five years of testing, each stored package was sprayed with a uniform, massive dose of Bacillus circulans spores.

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Development of an EO/IR Common Aperture Modular Multifunction Sensor

Geochronology – Methods and Case Studies. In situ U-Pb dating combined with SEM images on zircon crystals represent a powerful tool to reconstruct metamorphic and magmatic evolution of basements recording a long and complex geological history [ 1 – 3 ]. The development of high spatial and mass resolution microprobes e. The growth of zircon crystals, evidenced by their internal microtextures, can be easily revealed by SEM imaging by Cathodoluminescence CL and Variable Pressure Secondary Electrons VPSE detectors on separated grains or in situ within a polished thin rock section [ 6 , 4 , 7 ].

In acidic magmatic rocks abundant zircon crystals provide precise age data about magma emplacement and origin of source indicating the geodynamic context and the pertinence of terranes forming the continental crust.

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Literature

An essential part of any sterility-assurance programm is the chemical sterilization indicator. Etigam’s sterilization process indicators are manufactured as throughput process indicators to be used in the various sterilization processes. These indicators are designed to respond with a colorchange when the physical conditions of the sterilization process are met within the sterilization environment.

These indicators are to be used on individual items to be sterilized. The standard indicators are manufactured in different shapes round or rectangle and some also feature text.

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You need Adobe Reader 7. If Adobe Reader is not installed on your computer, click the button below and go to the download site. The operating principle was investigated and the origin of the deflection phenomenon was attributed to a nonuniform electric field induced by space-charge-controlled electrical conduction in the crystal. This novel effect has been called the “space-charge-controlled EO effect”. Optical beam scanners are used in various application fields including printing, displays, sensing, and telecommunications.

Electro-optic EO scanners have the attractive features of a rapid response and an arbitrary deflection angle compared with other technologies such as galvanic mirrors, polygon mirrors, microelectromechanical systems MEMS mirrors, and acousto-optic scanners. EO scanners refract optical beams by introducing a linear phase delay across the beam cross-section. The deflection angle is varied by electro-optically controlling the amount of the phase delay. A linear phase delay is commonly produced by forming an EO crystal [1], an electrode [2], or a ferroelectric domain [3] into a prism shape.

To make an ultrafast EO scanner, a linearly graded refractive index is induced by a linear distribution of the modulation index with appropriately designed electrodes [4]. Besides these techniques, it is also possible to induce a linear phase delay with a nonuniform electric field in an EO crystal. In this case, a linearly graded refractive index is induced by the EO effect and the beam is cumulatively refracted as it propagates through the crystal.

Fowler et al.

U.S. Food and Drug Administration

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For this reason, you should use the agency link listed below which will take you directly to the appropriate agency server where you can read the official version of this solicitation and download the appropriate forms and rules. Skip to main content. Department of Defense. Program Phase Year:. Topic Number:. Release Date: January 27, Open Date: February 28, Application Due Date: March 30, Close Date: March 30, Description: OBJECTIVE: To explore and develop the technologies needed to combine a number of passive and active electro-optical functions, currently being accomplished through multiple apertures, into a single aperture.

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JP3301106B2 – EO probe – Google Patents

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Eo beam-dating

This paper presents a review of experimental methods used to determine electro-optic EO coefficients in bulk materials. The techniques are based on the relations describing the electro-optic effect in one-beam-ellipsometric or two-beam-interferometric optical arrangements. The methods are classified according to the nature dc or ac of the electric field applied onto the sample static or dynamic methods and with respect of the measured physical quantity voltage, phase retardation, light beam intensity, etc.

Theoretical analysis and considerations of practical interest are presented in the article with particular attention paid to the resulting error in the determination of the EO coefficient associated with each method. A complete analysis of advantages and drawbacks of methods is finally given as a function of different experimental parameters such as the accuracy or sensitivity, the complexity of the implementation, the signal and the physical quantity used to derive the EO coefficient.

Date the Study started. Module. Beam. Beam Name. Radiation Type. Beam Limiting Device (MLC, Collim.) Wedge Portion of the beam delivered in segment.

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